La Casa de Pilatos (Pilate's House) is an Andalusian palace in Seville, Spain, which serves as the permanent residence of the Dukes of Medinaceli. It is an example of an Italian Renaissance building with Mudéjar elements and decorations. It is considered the prototype of the Andalusian palace.

The construction of this palace, which is adorned with precious azulejo tiles and well-kept gardens, was begun in 1483 by Pedro Enríquez de Quiñones, Adelantado Mayor of Andalucía, and his wife Catalina de Rivera, founder of the Casa de Alcalá, and completed by Pedro's son Fadrique Enríquez de Rivera (first Marquis of Tarifa), whose pilgrimage to Jerusalem in 1519 led to the building being given the name "Pilate's House".

On 20 October 1520, Don Fadrique returned from a trip through Europe and the Holy Land. During Lent in 1521, he inaugurated the observance in Seville of the Holy Via Crucis (Holy Way of the Cross). The route began in the Chapel of the Flagellations of his palace and ended at a pillar located not far from the Templete, or Cruz del Campo (The Cross of the Field,) located outside the city walls. This route ran the same distance of 1321 paces supposed to have separated the praetorium of Pontius Pilate from Calvary. The Marquis's palace, the Palacio de San Andrés, was then still partly under construction; it later became known as the Casa de Pilatos through its association with the Vía Crucis, and was much altered over the next few centuries. Popular imagination has since mistakenly identified the palace as a copy of the house of Pilate; thus the rooms have been named along the theme of the Passion of Christ: "Hall of the Praetorian", "Chapel of the Flagellations", etc. It was declared a National Monument in 1931. The oldest documentation of the name Casa de Pilatos is from 1754.

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