Located on a high bluff on the east bank of the Mississippi River across from Louisiana, Vicksburg was built by French colonists in 1719, and the outpost withstood an attack from the native Natchez people. It was incorporated as Vicksburg in 1825 after Methodist missionary Newitt Vick. In the American Civil War, it was a key Confederate river-port, and its July 1863 surrender to Ulysses S. Grant, along with the concurrent Battle of Gettysburg, marked the turning-point of the war. The city is home to three large installations of the United States Army Corps of Engineers, which has often been involved in local flood control.

During the American Civil War, the city finally surrendered during the Siege of Vicksburg, after which the Union Army gained control of the entire Mississippi River. The 47-day siege was intended to starve the city into submission. Its location atop a high bluff overlooking the Mississippi River proved otherwise impregnable to assault by federal troops. The surrender of Vicksburg by Confederate General John C. Pemberton on July 4, 1863, together with the defeat of General Robert E. Lee at Gettysburg the day before, has historically marked the turning point of the Civil War in the Union's favor

In the first few years after the Civil War, white Confederate veterans developed the Ku Klux Klan, beginning in Tennessee; it had chapters throughout the South and attacked freedmen and their supporters. It was suppressed about 1870. By the mid-1870s, new white paramilitary groups had arisen in the Deep South, including the Red Shirts in Mississippi, as whites struggled to regain political and social power over the black majority. Elections were marked by violence and fraud as white Democrats worked to suppress black Republican voting.

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