Sant'Ambrogio e Carlo al Corso (usually known simply as San Carlo al Corso) is a basilica church in Rome, Italy, facing onto the central part of the Via del Corso. The apse of the church faces across the street, the Mausoleum of Augustus on Via di Ripetta.

The church of the Saints Ambrogio and Carlo al Corso is the national church of the Lombards, to whom in 1471 Pope Sixtus IV gave, in recognition of their valuable construction work of the Sistine Chapel, the small church of S. Niccolò del Tufo, which was first restored and then dedicated to S. Ambrogio, the patron saint of Milan.

The central vault is frescoed with a Fall of the Rebel Angels (1677–1679) by Giacinto Brandi. The altarpiece, depicting the Saints Ambrose and Charles Borromeo with the Virgin and Jesus, was painted around 1685–1690 by Carlo Maratta. The stucco decoration was by Giacomo and Cosimo Fancelli. The statue of the saints was by Francesco Cavallini. Frescos of Justice and Peace were painted by Girolamo Troppa. There are also paintings by the baroque painter Giovanni Battista Beinaschi.

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